Rutin Inhibits F, G, N and O gonorrhea strains, 2008 WHO N-gonorrhea Reference strains, in vitro
Publication Date : 05/07/2020
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Rutin was isolated from methanol extract of the aerial part of Asparagus suaveolens using precipitation method. South Africans use Asparagus suaveolens to treat gonorrhea infections. The obtained Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectroscopy (LC-MS) data and visiting the published data on the isolation of rutin confirmed the structure. The 2008 WHO Neisseria gonorrhea reference strains were used to evaluate microbial activity of rutin against the gonorrhea strains. Rutin found to be bacteriostatic against WHO 2008 Neisseria gonorrhoea F, G, N and O strains with the minimum inhibition concentration of 0.40, 0.65, 0.22 and 0.65 mg/ml, respectively. In addition, rutin fare better than the reference drugs and bactericidal against K, L, M, and P strains. These results support the traditional use of Asparagus suaveolens against gonorrhea infections by South African indigenous people. To our knowledge, this is the first study indicating the activity of rutin against N.gonorrhea strains.
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